VetGen - The leader in veterinary genetic disease research and genetic disease detection services for purebred animals

Breeds Serviced

  • Beagle
  • Chihuahua
  • Curly-Coated Retriever
  • Dachshund - Miniature Longhaired
  • Dachshund - Miniature Longhaired
  • Dachshund - Miniature Smooth
  • Dachshund - Miniature Wirehaired
  • English Springer Spaniel
  • Field Spaniel
  • Papillon
  • Pug

Cone-Rod Dystrophy 1-PRA (Cord1-PRA)

Cone-Rod Dystrophy 1 - Progressive Retinal Atrophy (cord1 - PRA) is an inherited disease of the eye that affects the cone and rod cells that make up the dog's retina and often leading to blindness.

Researchers at Animal Health Trust have identified a DNA mutation, designated cord1, that is a major risk factor for development of PRA in Miniature Longhaired Dachshunds, Miniature Smooth Haired Dachshunds and English Springer Spaniel dogs. There is currently no treatment for the disease.

Cord1-PRA is inherited as an autosomal recessive trait.


The dog has 2 normal copies of the gene. The dog will never develop Cord1 - PRA, nor pass the mutation to its offspring.


A dog which has one copy of the gene with the mutation and one copy without the mutation. While it will not develop cord1 - PRA, it can pass the mutation onto its offspring and should therefore only be mated to clear dogs.


The dog has two copies of the cord1 - PRA mutation and therefore it will pass the mutation to its entire offspring. The dog will develop cord1 - PRA, however, there are variations in the age of onset in different dogs. Additional genes in the population or other factors that remain to be determined, can delay the effects of the cord1 mutation in some dogs.