Cystinuria in the Newfoundland dog is indicated by the presence of cystine stones in the kidney, bladder or ureter. Failure by the kidneys to reabsorb amino acids results in the formation of these stones.
It is an autosomal recessive disease thus an animal affected with the disease has inherited one copy of the mutation from each parent.
Inheriting only one copy from one parent yields carrier status. The disease is not present but the animal must be bred carefully to prevent creating affected offspring.
The disease in not present in your dog. When used for breeding, a Clear dog will not pass on the disease gene.
One copy of the disease gene is present in your dog, but it will not exhibit disease symptoms. Carriers will not have related medical problems, but will pass on the disease gene 50% of the time.
This finding indicates that two copies of the disease gene are present in the dog. Unfortunately, the dog will be medically affected by the disease.