- Golden Retriever
DEB-Dystrophic Epidermolysis Bullosa
Epidermolysis Bullosa ( EB ) syndrome is a group of immune-mediated sub-epidermal blistering skin diseases. The main forms of EB are EB simplex, junctional EB, and dystrophic EB.
DEB has been described in the Golden Retriever. The disease is caused by mutations in the gene encoding collagen VII resulting in the lack of collage in the skin and mucosa. The disease is characterized by blisters and erosions in the oral and esophageal epithelia, nails dystrophy and growth retardation.
DEB is an autosomal recessive disease.