VetGen - The leader in veterinary genetic disease research and genetic disease detection services for purebred animals

Breeds Serviced

  • Alaskan Klee Kai
  • Beagle
  • Giant Schnauzer
  • Scottish Deerhound

Factor VII deficiency

Factor VII (FVII) deficiency, an autosomal recessive trait originally identified in Beagles, is associated with a mild to moderate bleeding. Recently, the mutation responsible for this recessive trait has been identified by Dr Urs Giger and researchers at the University of Pennsylvania.

The test, available at VetGen, detects this mutation and shows whether a dog is affected (2 copies), clear (0 copies) or carrier (1 copy). Carriers, who have one normal and one mutant/diseased gene/allele, have normal coagulation and routine coagulation tests and are therefore not at risk for bleeding.

The test is effective in Airedale, Alaskan Klee Kai, Beagle, Giant Schnauzer and Scottish Deerhound to date.

Reference:
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. (2006) A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. Dec; 4 (12):2616-22.