Musladin-Lueke Syndrome (MLS)
Musladin-Lueke Syndrome (MLS) is a hereditary disorder affecting the development and structure of connective tissue in Beagle dogs. It tends to affect multiple organs, including bone, heart, skin, and muscle.
MLS is inherited as a recessive trait. Current evidence suggests that dogs that have two copies of the mutant gene are affected with MLS, though the severity of clinical signs can be variable. Some animals can live a fairly normal life with the disease. However others cannot be kept comfortable and may require euthanasia. Dogs that can function normally at maturity generally do not progress. This syndrome can be prevented by testing all beagles before they are bred.