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PK

Pyruvate kinase deficiency in Basenji dogs is an inherited lack of an enzyme (pyruvate kinase) in the red blood cells of an affected animal. This enzyme is required for red blood cells to survive for a normal length of time in the blood of the animal, and when it is missing, the red blood cells break down and are destroyed prematurely. This leads to lifelong anemia in the affected animal. The symptoms of anemia are lack of energy, low exercise tolerance, easy fatiguability, and probably reduced fertility.

This disease is inherited as an autosomal recessive. This means that affected animals have two doses of the mutant gene. Dogs that have one mutant and one normal gene are called carriers. Carriers are not ill (they do not have anemia), but can produce affected offspring if mated to another carrier.

The VetGen solution

Based on research conducted at Michigan State University and the University of Michigan leading to the discovery of the mutation causing PK in Basenjis, VetGen is proud to exclusively offer a non-invasive, highly reliable DNA-based test to detect PK. This test provides breeders and owners a definitive diagnosis whether their dog is PK "Affected", "Carrier", or "Clear". With this information in hand, Basenji breeders and owners have key insight into their bloodstock and can proceed to make informed decisions about training, showing, and breeding plans for each dog.

By following the simple instructions provided in VetGen's DNA Sample Collection Kit, dog owners and breeders collect DNA samples using a soft cheek brush. By gently brushing the inside of the dog's cheek, cells containing DNA are removed. It is this DNA sample that VetGen analyzes to determine the genetic status of each dog. As soon as VetGen receives the completed DNA Sample Collection Kit, the DNA samples are processed and a diagnosis is formed. Within two weeks, this diagnosis is provided to the customer in a summary report.

Useful for dogs of any age, the DNA sample collection, analysis, and reporting activities can be completed before puppies are placed at 6 to 10 weeks. As a supplement to the summary report, VetGen can assist its customers with genetic counseling services to further help them make informed breeding decisions to eliminate the PK gene from their bloodlines while maintaining the integrity of their breed.