Human DNA Helps Man's Best Friend
Cloning of human gene leads to breakthrough genetic discover
(Ann Arbor, Mich.) - VetGen, Inc. has announced a major breakthrough in
canine genetic research with the introduction of a new test that could
eradicate a potentially fatal disease in dogs. Researchers discovered the
genetic mutation responsible for canine von Willebrand's Disease (vWD),
a bleeding disorder similar to hemophilia, after the gene was successfully
cloned in humans. VetGen, a Michigan-based company specializing in canine
disease detection services, has developed the first reliable, non-invasive
test for vWD in Scottish Terriers.
The research project, headed by University of Michigan geneticist
Dr. George Brewer, was a joint effort between VetGen, Michigan State University
and the University of Michigan. Researchers focused their initial vWD study
on Scottish Terriers, one of the primary breeds affected by the disease,
although work is underway to analyze the gene in several other breeds.
When used by Scottie breeders, the VetGen vWD test can provide
owners with the assurance that their dogs and puppies are free of the disease,
Another advantage of VetGen's vWD test is that it can be performed on dogs
of any age. In addition, breeders who use VetGen's vWD test can register
the results of their dog's test with the Orthopedic Foundation for Animals.
To test their animals, owners simply take a sample of their
dog's DNA by gently wiping VetGen-provided cheek swabs inside the dog's
mouth, removing cells containing DNA. The swabs are then mailed to VetGen's
laboratory and tested for vWD. After testing the sample, VetGen will send
a summary of the results to owners. This information is especially helpful
to Scottish Terrier breeders, as they can now virtually guarantee prospective
buyers a puppy is clear of vWD.
VetGen also offers genetic tests for other canine diseases,
including copper toxicosis in Bedlington Terriers, pyruvic kinase deficiency
in Basenjis, phosphofructokinase deficiency in Springer and Cocker Spaniels
and progressive retinal atrophy in Irish Setters.
VetGen, a Sloan Enterprises affiliate, is a molecular genetics
company and the market leader in canine disease detection services that
also offers canine DNA profiling. The company is based in Ann Arbor, Mich.,
and draws upon several years of extensive research conducted at the University
of Michigan and Michigan State University. Original funding for the university
research was provided by grants from Scottish Terrier clubs and breeders,
the American Kennel Club, the Morris Animal Foundation and the Orthopedic
Foundation for Animals.
Q & A on VetGen and vWD Testing
What is von Willebrand's Disease (vWD) and who does it affect?
Von Willebrand's Disease (vWD) is named after a Finnish physician
Erick von Willebrand who discovered the disease in humans. vWD is a bleeding
disorder prevalent in Scottish Terriers and several other breeds. vWD is
similar to hemophilia in humans, as it creates a condition which inhibits
a dog's ability to stop bleeding. There is currently no known cure or effective-treatment
for vWD.
Dr. George Brewer, founder of VetGen, shows how simple it is to collect a DNA
sample with the VetGen provided cheek swab. Scottie breeders can have the results
of their dog's test within two weeks after sending their dog's sample to VetGen.
Is vWD fatal?
vWD can be fatal, especially in situations such as accidental injuries or surgery.
Affected dogs may bleed spontaneously or display uncontrollable bleeding after
an injury or surgery.
Do dog owners have to bring their dog to VetGen to have the test performed?
No. DNA samples are taken by dog owners using a VetGen Sample Collection Kit.
The dog owner, using a cheek swab provided by VetGen, simply runs the swab inside
the dog's mouth, gently scraping the lining of each of the dog's cheeks to get
a sample. This process is pain free and takes only about twenty seconds. The
swab with the sample is then placed back in its container and mailed to VetGen.
Within two to four weeks, a summary report of the findings will be mailed to
the dog owner.
How does VetGen get all of that information from only a cheek swab?
The cells that line the inside of a dog's cheek are continually being renewed,
with new cells replacing the old ones. The cheek swab gently removes some of
these old dead cells that contain perfect DNA samples for testing.
How reliable is the VetGen test for vWD?
VetGen genetic testing for vWD in Scottish Terriers is 100% accurate in its DNA
analysis.
Is VetGen's test for vWD recognized by any veterinary organizations?
VetGen's vWD test is recognized by the Orthopedic Foundation for Animals (OFA).
Additionally, the results of your dog's vWD test can be formally registered with
the OFA.
Does any other company perform this test?
No. VetGen is the only company offering Scottish Terrier breeders and owners
this invaluable service.
For further information call:
VetGen at 1-800-4VETGEN.
The Bagpiper
1996 Number 2
By Dr. George Brewer
Canine: vWD Patents
US Patent No. 6,040,143 and 6,074,832
Licensed Exclusively by The Board of Regents of the
University of Michigan (Ann Arbor, MI) System to VetGen LLC
Go To: Genetic Test for von Willebrand's Disease - Scottish Terriers
Home: to VetGen's Page
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