VetGen - Veterinary Genetic Services

VetGen Current Limited Time Special

Factor VII deficiency

Factor VII (FVII) deficiency, an autosomal recessive trait originally identified in Beagles, is associated with a mild to moderate bleeding. Recently, the mutation responsible for this recessive trait has been identified by Dr Urs Giger and researchers at the University of Pennsylvania.

The test, available at VetGen, detects this mutation and shows whether a dog is affected (2 copies), clear (0 copies) or carrier (1 copy). Carriers, who have one normal and one mutant/diseased gene/allele, have normal coagulation and routine coagulation tests and are therefore not at risk for bleeding.

Musladin-Lueke Syndrome (MLS)

Musladin-Lueke Syndrome (MLS) is a hereditary disorder affecting the development and structure of connective tissue in Beagle dogs. It tends to affect multiple organs, including bone, heart, skin, and muscle.

MLS is inherited as a recessive trait. Current evidence suggests that dogs that have two copies of the mutant gene are affected with MLS, though the severity of clinical signs can be variable. Some animals can live a fairly normal life with the disease. However others cannot be kept comfortable and may require euthanasia. Dogs that can function normally at maturity generally do not progress. This syndrome can be prevented by testing all beagles before they are bred.