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Breeds Serviced

  • Beagle

Catalase Deficiency

Catalase deficiency (hypocatalasemia or acatalasia) is a rare autosomal recessive disorder that is caused by mutation in the gene responsible for the production of catalase, an anti-oxidative enzyme. Catalase enzymes are responsible for regulating the metabolism of hydrogen peroxide, one of many by-products generated during the respiration process during which molecular oxygen is transformed. Dogs with catalase deficiency are particularly sensitive to hydrogen peroxide’s oxidative stress, causing painful oral sores and altering other important metabolic processes.