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PRA (cord1/crd4)

The PRA associated with the cord1/crd4 mutation is an inherited disease of the eye that affects the cone and rod cells that make up the dog's retina and often leading to blindness. The age of onset is highly variable but when present is usually detectable by the age of three.

Researchers at Animal Health Trust have identified a DNA mutation, designated cord1, that is a major risk factor for development of PRA in Miniature Longhaired Dachshunds, Miniature Smooth Haired Dachshunds and English Springer Spaniel dogs as well as several other breeds. There is currently no treatment for the disease. The cord1 mutation is incompletely penetrant, which means not all dogs with two copies of the mutation will develop PRA.

Result types: clear, carrier, affected

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