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Upper Airway Syndrome (UAS)

A variation in the AdamTS3 gene has been identified as a risk marker for Upper Airway Syndrome in the Norwich Terrier. The disease occurs at a high enough frequency that in Switzerland where this research was undertaken, all proposed breeding pairs are required to undergo an upper airway clinical examination. Those animals receiving high scores are not allowed to breed. Our test is based on the findings of the Swiss research which shows that animals with two copies of the risk allele are at a significantly greater risk for the disease.

The same mutation has also been identified in The French and English Bulldog breeds which have a similar condition known as BOAS, or Brachycephalic Open Airway Syndrome. Research is ongoing to determine the possible correlation of this risk allele to BOAS.

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